{"id":41,"date":"2021-01-27T11:00:58","date_gmt":"2021-01-27T10:00:58","guid":{"rendered":"http:\/\/www3.uah.es\/secuah\/2021\/?p=41"},"modified":"2021-01-27T11:00:58","modified_gmt":"2021-01-27T10:00:58","slug":"dianas-2021-10-1-e202103a01-arranz-nicolas-etal-diacylglycerol-kinase-zeta-limits-il-2-dependent-control-of-pd-1-expression-in-tumor-infiltrating-t-lymphocytes","status":"publish","type":"post","link":"https:\/\/dianas.web.uah.es\/journal\/dianas-2021-10-1-e202103a01-arranz-nicolas-etal-diacylglycerol-kinase-zeta-limits-il-2-dependent-control-of-pd-1-expression-in-tumor-infiltrating-t-lymphocytes\/","title":{"rendered":"dianas 10 (1) Arranz-Nicol\u00e1s etal 2021 Diacylglycerol kinase zeta limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes."},"content":{"rendered":"<div class='ad_single_article'>\n<p class='ad_single_article_SO'><a href='https:\/\/dianas.web.uah.es\/journal\/dianas-10-1\/#dianas-2021-10-1-e202103a01-arranz-nicolas-etal-diacylglycerol-kinase-zeta-limits-il-2-dependent-control-of-pd-1-expression-in-tumor-infiltrating-t-lymphocytes'>dianas 10(1)<br \/><\/a> &gt; <a href='https:\/\/dianas.web.uah.es\/journal\/dianas-2021-10-1-e202103a01-arranz-nicolas-etal-diacylglycerol-kinase-zeta-limits-il-2-dependent-control-of-pd-1-expression-in-tumor-infiltrating-t-lymphocytes\/'>Arranz-Nicol\u00e1s etal<br \/><\/a><\/p>\n\n<p class='signature'>dianas | Vol 10 Num 1 | marzo  2021 | e202103a01<br \/><\/p>\n\n<p class='w_authors ad_single_article_authors'>Javier&nbsp;Arranz-Nicol\u00e1s<br&nbsp;\/>, Miguel&nbsp;Martin-Salgado<br&nbsp;\/>, Cristina&nbsp;Rodr\u00edguez-Rodr\u00edguez<br&nbsp;\/>, Rosa&nbsp;Li\u00e9bana<br&nbsp;\/>, Mar\u00eda&nbsp;del&nbsp;Carmen&nbsp;Moreno-Ort\u00edz<br&nbsp;\/>, Judith&nbsp;Leitner<br&nbsp;\/>, Peter&nbsp;Steinberger<br&nbsp;\/>, Antonia&nbsp;\u00c1vila-Flores<br&nbsp;\/>, Isabel&nbsp;Merida<br&nbsp;\/><\/p>\n\n<p class='w_address ad_single_article_address'>Centro Nacional de Biotecnolog\u00eda (CNB-CSIC).<br \/><\/p>\n\n<p class='w_mail ad_single_article_mail'>jarranz@cnb.csic.es<br \/><\/p>\n\n<p class='w_meeting ad_single_article_meeting'>VI Congreso de Se\u00f1alizaci\u00f3n Celular, SECUAH 2021.<br \/><br \/>\n29 de marzo a 30 de abril, 2021. Universidad de Alcal\u00e1. Alcal\u00e1 de Henares, Madrid. Espa\u00f1a.<br \/><\/p>\n\n<p class='w_abstract_caption ad_single_article_abstract_caption'>Resumen<\/p>\n<p class='w_abstract ad_single_article_abstract'>Background: The inhibitory functions triggered by the programmed cell death-1 (PD-1) receptor following binding to its ligand (PD-L1) protect healthy organs from cytotoxic T cells, and neutralize anti-tumor T cell attack. Antibody-based therapies to block PD-1\/PD-L1 interaction have yielded notable results, but most patients eventually develop resistance. This failure is attributed to CD8+ T cells achieving hypo-responsive states from which recovery is hardly feasible. Dysfunctional T cell phenotypes are favored by a sustained imbalance in the diacylglycerol (DAG)- and Ca2+-regulated transcriptional programs. In mice, DAG kinase zeta (DGKzeta) facilitates DAG consumption, limiting T cell activation and cytotoxic T cell responses. DGKzeta deficiency facilitates tumor rejection in mice without apparent adverse autoimmune effects. Despite its therapeutic potential, little is known about DGKzeta function in human T cells, and no known inhibitors target this isoform.<\/p><\/p>\n\n<div class='ad_single_article_citation_box'>\n<\/div>\n\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,6,65,56,64],"tags":[],"class_list":["post-41","post","type-post","status-publish","format-standard","hentry","category-article","category-cancer","category-dianas-vol-10-num-1","category-sesion-a","category-vols-10-19"],"_links":{"self":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/posts\/41","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/comments?post=41"}],"version-history":[{"count":0,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/posts\/41\/revisions"}],"wp:attachment":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/media?parent=41"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/categories?post=41"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/tags?post=41"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}