{"id":414,"date":"2016-09-01T00:00:18","date_gmt":"2016-09-01T00:00:18","guid":{"rendered":"http:\/\/www3.uah.es\/dianas\/journal\/?p=414"},"modified":"2026-08-31T23:28:34","modified_gmt":"2026-08-31T21:28:34","slug":"dianas-5-2","status":"publish","type":"post","link":"https:\/\/dianas.web.uah.es\/journal\/dianas-5-2\/","title":{"rendered":"Dianas 5(2)"},"content":{"rendered":"\n<style type='text\/css'>\n.featured-image {display:none;}\n.post-thumbnail {display:none;}\n\n.adj_issue_cover_thumbnail {\n\tborder: none;\n\tmax-width: 100%;\n\theight: auto;\n\tdisplay: block;\n\tbackground: #ccc;\n\ttransition: transform .2s ease-in-out;\n}\n\n@media screen and (min-width: 20em) {\n\t.adj_issue_cover_thumbnail {\n\t\twidth: 50%;\n\t}\n}\n@media screen and (min-width: 40em) {\n\t.adj_issue_cover_thumbnail {\n\t\twidth: 25%;\n\t}\n}\n<\/style>\n<h5>dianas Vol. 5 | No. 2 | Septiembre 2016<\/h5>\n<!-- h5>article+article+dianas vol 5 num 2<\/h5 -->\n<img decoding=\"async\" class=\"adj_issue_cover_thumbnail\" src=\"https:\/\/dianas.web.uah.es\/journal\/wp-content\/uploads\/2016\/09\/dianas_5_2_septiembre_2016.jpg\" alt=\"Dianas 5(2)\">\n<!-- was content --><br \/>\nMonogr\u00e1fico<\/p>\n<p><b>X M\u00e1ster en Dianas Terap\u00e9uticas en Se\u00f1alizaci\u00f3n Celular, Investigaci\u00f3n y Desarrollo &#8211; 2015-2016<\/b><\/p>\n<p>Editores: M. J. Carmena y A. Domingo<\/p>\n<p>El presente n\u00famero incluye art\u00edculos correspondientes a Proyectos Fin de M\u00e1ster seleccionados entre los presentados y defendidos al finalizar la d\u00e9cima edici\u00f3n del M\u00e1ster en Dianas Terap\u00e9uticas en Se\u00f1alizaci\u00f3n Celular, Investigaci\u00f3n y Desarrollo, en el curso 2015-2016.<br \/>\n<h1>Tabla de contenidos<\/h1>\t\n<!-- h1>Tabla de contenidos<\/h1 -->\n\t\n<div class=\"ad_journal_issue_toc\">   \n\t<div class=\"ad_journal_issue_toc_wrap\">\n\t\t<!-- articles: -->\n<div class='ad_journal_issue_toc_article' \n\tid='dianas-2016-5-2-e20160901-requena-triguero-etal-aplicaciones-quimioinformaticas-en-el-descubrimiento-de-farmacos' \n\tonclick=\"document.location.href='https:\/\/dianas.web.uah.es\/journal\/dianas-2016-5-2-e20160901-requena-triguero-etal-aplicaciones-quimioinformaticas-en-el-descubrimiento-de-farmacos\/'\" \n\tonmouseover=\"this.className='ad_journal_issue_toc_article_hover'\" \n\tonmouseout=\"this.className='ad_journal_issue_toc_article'\" \n>\n\t\t  <div class='ad_journal_issue_toc_article_title' >Aplicaciones quimioinform\u00e1ticas en el descubrimiento de f\u00e1rmacos.<\/div>\n\t\t  <div class='ad_journal_issue_toc_article_authors' >Carlos Requena Triguero, Carlos Roca Magad\u00e1n, Victor Sebasti\u00e1n P\u00e9rez, Nuria E. Campillo Mart\u00edn<\/div>\n\t\t  <div class='ad_journal_issue_toc_article_where' ><a href='https:\/\/dianas.web.uah.es\/journal\/dianas-2016-5-2-e20160901-requena-triguero-etal-aplicaciones-quimioinformaticas-en-el-descubrimiento-de-farmacos\/'>Dianas. 2016 Sep; 5(2):e20160901.<\/a><\/div>\n\t\t  <!-- div class='ad_journal_issue_toc_article_authors' ><a href='dianas_2016_5_2_e20160901_requena-triguero_etal.pdf' target='_blank'>pdf<\/a><\/div -->\n\t\t  <!-- div class='ad_journal_issue_toc_article_content' ><\/div -->\n<\/div><div class='ad_journal_issue_toc_article' \n\tid='dianas-2016-5-2-e20160902-de-la-usada-molinero-etal-lrrk2-como-nueva-diana-terapeutica-en-retinosis-pigmentaria' \n\tonclick=\"document.location.href='https:\/\/dianas.web.uah.es\/journal\/dianas-2016-5-2-e20160902-de-la-usada-molinero-etal-lrrk2-como-nueva-diana-terapeutica-en-retinosis-pigmentaria\/'\" \n\tonmouseover=\"this.className='ad_journal_issue_toc_article_hover'\" \n\tonmouseout=\"this.className='ad_journal_issue_toc_article'\" \n>\n\t\t  <div class='ad_journal_issue_toc_article_title' >LRRK2 como nueva diana terap\u00e9utica en retinosis pigmentaria.<\/div>\n\t\t  <div class='ad_journal_issue_toc_article_authors' >Eduardo de la Usada Molinero, Josefa Zald\u00edvar Diez de Bonilla, Loreto Mart\u00ednez Gonz\u00e1lez, Ana Mart\u00ednez Gil<\/div>\n\t\t  <div class='ad_journal_issue_toc_article_where' ><a href='https:\/\/dianas.web.uah.es\/journal\/dianas-2016-5-2-e20160902-de-la-usada-molinero-etal-lrrk2-como-nueva-diana-terapeutica-en-retinosis-pigmentaria\/'>Dianas. 2016 Sep; 5(2):e20160902.<\/a><\/div>\n\t\t  <!-- div class='ad_journal_issue_toc_article_authors' ><a href='dianas_2016_5_2_e20160902_de-la-usada-molinero_etal.pdf' target='_blank'>pdf<\/a><\/div -->\n\t\t  <!-- div class='ad_journal_issue_toc_article_content' ><\/div -->\n<\/div><div class='ad_journal_issue_toc_article' \n\tid='dianas-2016-5-2-e20160903-torres-valle-y-perez-analisis-critico-de-ensayos-clinicos-oncologicos' \n\tonclick=\"document.location.href='https:\/\/dianas.web.uah.es\/journal\/dianas-2016-5-2-e20160903-torres-valle-y-perez-analisis-critico-de-ensayos-clinicos-oncologicos\/'\" \n\tonmouseover=\"this.className='ad_journal_issue_toc_article_hover'\" \n\tonmouseout=\"this.className='ad_journal_issue_toc_article'\" \n>\n\t\t  <div class='ad_journal_issue_toc_article_title' >An\u00e1lisis cr\u00edtico de ensayos cl\u00ednicos oncol\u00f3gicos.<\/div>\n\t\t  <div class='ad_journal_issue_toc_article_authors' >Lorena Torres Valle, Mar\u00eda Isabel P\u00e9rez<\/div>\n\t\t  <div class='ad_journal_issue_toc_article_where' ><a href='https:\/\/dianas.web.uah.es\/journal\/dianas-2016-5-2-e20160903-torres-valle-y-perez-analisis-critico-de-ensayos-clinicos-oncologicos\/'>Dianas. 2016 Sep; 5(2):e20160903.<\/a><\/div>\n\t\t  <!-- div class='ad_journal_issue_toc_article_authors' ><a href='dianas_2016_5_2_e20160903_torres-valle_y_perez.pdf' target='_blank'>pdf<\/a><\/div -->\n\t\t  <!-- div class='ad_journal_issue_toc_article_content' ><\/div -->\n<\/div><div class='ad_journal_issue_toc_article' \n\tid='dianas-2016-5-2-e20160905-lin-etal-diseno-y-elaboracion-del-acondicionador-capilar-rf' \n\tonclick=\"document.location.href='https:\/\/dianas.web.uah.es\/journal\/dianas-2016-5-2-e20160905-lin-etal-diseno-y-elaboracion-del-acondicionador-capilar-rf\/'\" \n\tonmouseover=\"this.className='ad_journal_issue_toc_article_hover'\" \n\tonmouseout=\"this.className='ad_journal_issue_toc_article'\" \n>\n\t\t  <div class='ad_journal_issue_toc_article_title' >Dise\u00f1o y elaboraci\u00f3n del acondicionador capilar RF.<\/div>\n\t\t  <div class='ad_journal_issue_toc_article_authors' >Wanqing Lin, Alicia L\u00f3pez Garc\u00eda, Sonia Gonz\u00e1lez Cenisergue<\/div>\n\t\t  <div class='ad_journal_issue_toc_article_where' ><a href='https:\/\/dianas.web.uah.es\/journal\/dianas-2016-5-2-e20160905-lin-etal-diseno-y-elaboracion-del-acondicionador-capilar-rf\/'>Dianas. 2016 Sep; 5(2):e20160905.<\/a><\/div>\n\t\t  <!-- div class='ad_journal_issue_toc_article_authors' ><a href='dianas_2016_5_2_e20160905_lin_etal.pdf' target='_blank'>pdf<\/a><\/div -->\n\t\t  <!-- div class='ad_journal_issue_toc_article_content' ><\/div -->\n<\/div><div class='ad_journal_issue_toc_article' \n\tid='dianas-2016-5-2-e20160904-martin-diaz-etal-generacion-de-un-alelo-knockout-del-gen-has1-mediante-crisprcas9-en-un-modelo-de-raton-de-adenocarcinoma-pancreatico-ductal' \n\tonclick=\"document.location.href='https:\/\/dianas.web.uah.es\/journal\/dianas-2016-5-2-e20160904-martin-diaz-etal-generacion-de-un-alelo-knockout-del-gen-has1-mediante-crisprcas9-en-un-modelo-de-raton-de-adenocarcinoma-pancreatico-ductal\/'\" \n\tonmouseover=\"this.className='ad_journal_issue_toc_article_hover'\" \n\tonmouseout=\"this.className='ad_journal_issue_toc_article'\" \n>\n\t\t  <div class='ad_journal_issue_toc_article_title' >Generaci\u00f3n de un alelo knockout del gen Has1 mediante CRISPR\/Cas9 en un modelo de rat\u00f3n de adenocarcinoma pancre\u00e1tico ductal.<\/div>\n\t\t  <div class='ad_journal_issue_toc_article_authors' >Laura Mart\u00edn D\u00edaz, Carmen Guerra, Mariano Barbacid<\/div>\n\t\t  <div class='ad_journal_issue_toc_article_where' ><a href='https:\/\/dianas.web.uah.es\/journal\/dianas-2016-5-2-e20160904-martin-diaz-etal-generacion-de-un-alelo-knockout-del-gen-has1-mediante-crisprcas9-en-un-modelo-de-raton-de-adenocarcinoma-pancreatico-ductal\/'>Dianas. 2016 Sep; 5(2):e20160904.<\/a><\/div>\n\t\t  <!-- div class='ad_journal_issue_toc_article_authors' ><a href='dianas_2016_5_2_e20160904_martin-diaz_etal.pdf' target='_blank'>pdf<\/a><\/div -->\n\t\t  <!-- div class='ad_journal_issue_toc_article_content' ><\/div -->\n<\/div><div class='ad_journal_issue_toc_article' \n\tid='dianas-2016-5-2-e20160906-gargantilla-lopez-etal-sintesis-y-evaluacion-de-compuestos-con-actividad-antitumoral-derivados-de-nuevos-activadores-de-ampk' \n\tonclick=\"document.location.href='https:\/\/dianas.web.uah.es\/journal\/dianas-2016-5-2-e20160906-gargantilla-lopez-etal-sintesis-y-evaluacion-de-compuestos-con-actividad-antitumoral-derivados-de-nuevos-activadores-de-ampk\/'\" \n\tonmouseover=\"this.className='ad_journal_issue_toc_article_hover'\" \n\tonmouseout=\"this.className='ad_journal_issue_toc_article'\" \n>\n\t\t  <div class='ad_journal_issue_toc_article_title' >S\u00edntesis y evaluaci\u00f3n de compuestos con actividad antitumoral derivados de nuevos activadores de AMPK.<\/div>\n\t\t  <div class='ad_journal_issue_toc_article_authors' >Marta Gargantilla L\u00f3pez, Sergio Quesada S\u00e1nchez, Ana Castro Morera<\/div>\n\t\t  <div class='ad_journal_issue_toc_article_where' ><a href='https:\/\/dianas.web.uah.es\/journal\/dianas-2016-5-2-e20160906-gargantilla-lopez-etal-sintesis-y-evaluacion-de-compuestos-con-actividad-antitumoral-derivados-de-nuevos-activadores-de-ampk\/'>Dianas. 2016 Sep; 5(2):e20160906.<\/a><\/div>\n\t\t  <!-- div class='ad_journal_issue_toc_article_authors' ><a href='dianas_2016_5_2_e20160906_gargantilla-lopez_etal.pdf' target='_blank'>pdf<\/a><\/div -->\n\t\t  <!-- div class='ad_journal_issue_toc_article_content' ><\/div -->\n<\/div><div class='ad_journal_issue_toc_article' \n\tid='dianas-2016-5-2-e20160907-garcia-soriano-etal-puesta-a-punto-de-ensayos-de-cuantificacion-de-dimerizacion-y-actividad-de-la-superoxido-dismutasa-de-hierro-a-de-leishmania-infantum' \n\tonclick=\"document.location.href='https:\/\/dianas.web.uah.es\/journal\/dianas-2016-5-2-e20160907-garcia-soriano-etal-puesta-a-punto-de-ensayos-de-cuantificacion-de-dimerizacion-y-actividad-de-la-superoxido-dismutasa-de-hierro-a-de-leishmania-infantum\/'\" \n\tonmouseover=\"this.className='ad_journal_issue_toc_article_hover'\" \n\tonmouseout=\"this.className='ad_journal_issue_toc_article'\" \n>\n\t\t  <div class='ad_journal_issue_toc_article_title' >Puesta a punto de ensayos de cuantificaci\u00f3n de dimerizaci\u00f3n y actividad de la super\u00f3xido dismutasa de hierro A de <em>Leishmania infantum<\/em><\/div>\n\t\t  <div class='ad_journal_issue_toc_article_authors' >Juan Carlos Garc\u00eda Soriano, H\u00e9ctor Elessar de Lucio Ortega, Antonio Jim\u00e9nez Ru\u00edz<\/div>\n\t\t  <div class='ad_journal_issue_toc_article_where' ><a href='https:\/\/dianas.web.uah.es\/journal\/dianas-2016-5-2-e20160907-garcia-soriano-etal-puesta-a-punto-de-ensayos-de-cuantificacion-de-dimerizacion-y-actividad-de-la-superoxido-dismutasa-de-hierro-a-de-leishmania-infantum\/'>Dianas. 2016 Sep; 5(2):e20160907.<\/a><\/div>\n\t\t  <!-- div class='ad_journal_issue_toc_article_authors' ><a href='dianas_2016_5_2_e20160907_garcia-soriano_etal.pdf' target='_blank'>pdf<\/a><\/div -->\n\t\t  <!-- div class='ad_journal_issue_toc_article_content' ><\/div -->\n<\/div><div class='ad_journal_issue_toc_article' \n\tid='dianas-2016-5-2-e20160908-fernandez-garcia-etal-puesta-a-punto-y-utilizacion-de-leishmania-tarentolae-como-sistema-de-expresion-de-proteinas-para-su-posterior-purificacion-y-cristalizacion-aplicacion' \n\tonclick=\"document.location.href='https:\/\/dianas.web.uah.es\/journal\/dianas-2016-5-2-e20160908-fernandez-garcia-etal-puesta-a-punto-y-utilizacion-de-leishmania-tarentolae-como-sistema-de-expresion-de-proteinas-para-su-posterior-purificacion-y-cristalizacion-aplicacion\/'\" \n\tonmouseover=\"this.className='ad_journal_issue_toc_article_hover'\" \n\tonmouseout=\"this.className='ad_journal_issue_toc_article'\" \n>\n\t\t  <div class='ad_journal_issue_toc_article_title' >Puesta a punto y utilizaci\u00f3n de <i>Leishmania tarentolae<\/i> como sistema de expresi\u00f3n de prote\u00ednas para su posterior purificaci\u00f3n y cristalizaci\u00f3n. Aplicaci\u00f3n a la prote\u00edna LiEndoG.<\/div>\n\t\t  <div class='ad_journal_issue_toc_article_authors' >Fernando Fern\u00e1ndez Garc\u00eda, Cristina Oliva Correia, Antonio Jim\u00e9nez Ruiz<\/div>\n\t\t  <div class='ad_journal_issue_toc_article_where' ><a href='https:\/\/dianas.web.uah.es\/journal\/dianas-2016-5-2-e20160908-fernandez-garcia-etal-puesta-a-punto-y-utilizacion-de-leishmania-tarentolae-como-sistema-de-expresion-de-proteinas-para-su-posterior-purificacion-y-cristalizacion-aplicacion\/'>Dianas. 2016 Sep; 5(2):e20160908.<\/a><\/div>\n\t\t  <!-- div class='ad_journal_issue_toc_article_authors' ><a href='dianas_2016_5_2_e20160908_fernandez-garcia_etal.pdf' target='_blank'>pdf<\/a><\/div -->\n\t\t  <!-- div class='ad_journal_issue_toc_article_content' ><\/div -->\n<\/div><div class='ad_journal_issue_toc_article' \n\tid='dianas-2016-5-2-e20160909-carrion-marchante-etal-estudio-de-la-estabilidad-de-aptameros-generados-frente-a-la-proteina-4e-bp1' \n\tonclick=\"document.location.href='https:\/\/dianas.web.uah.es\/journal\/dianas-2016-5-2-e20160909-carrion-marchante-etal-estudio-de-la-estabilidad-de-aptameros-generados-frente-a-la-proteina-4e-bp1\/'\" \n\tonmouseover=\"this.className='ad_journal_issue_toc_article_hover'\" \n\tonmouseout=\"this.className='ad_journal_issue_toc_article'\" \n>\n\t\t  <div class='ad_journal_issue_toc_article_title' >Estudio de la estabilidad de apt\u00e1meros generados frente a la prote\u00edna 4E-BP1.<\/div>\n\t\t  <div class='ad_journal_issue_toc_article_authors' >Rebeca Carri\u00f3n Marchante, Ana Garc\u00eda Sacrist\u00e1n, Celia Pinto D\u00edez, Mar\u00eda Elena Mart\u00edn, V\u00edctor M. Gonz\u00e1lez<\/div>\n\t\t  <div class='ad_journal_issue_toc_article_where' ><a href='https:\/\/dianas.web.uah.es\/journal\/dianas-2016-5-2-e20160909-carrion-marchante-etal-estudio-de-la-estabilidad-de-aptameros-generados-frente-a-la-proteina-4e-bp1\/'>Dianas. 2016 Sep; 5(2):e20160909.<\/a><\/div>\n\t\t  <!-- div class='ad_journal_issue_toc_article_authors' ><a href='dianas_2016_5_2_e20160909_carrion-marchante_etal.pdf' target='_blank'>pdf<\/a><\/div -->\n\t\t  <!-- div class='ad_journal_issue_toc_article_content' ><\/div -->\n<\/div>\n\t<\/div><!-- \/.ad_journal_issue_toc_wrap -->\n<\/div><!-- \/ad_.journal_issue_toc -->\t\n\t\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":5637,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36,4,2],"tags":[],"class_list":["post-414","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dianas-vol-5-num-2","category-issue","category-vols-1-9"],"_links":{"self":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/posts\/414","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/comments?post=414"}],"version-history":[{"count":1,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/posts\/414\/revisions"}],"predecessor-version":[{"id":5638,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/posts\/414\/revisions\/5638"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/media\/5637"}],"wp:attachment":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/media?parent=414"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/categories?post=414"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/tags?post=414"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}