{"id":4262,"date":"2022-05-05T18:24:01","date_gmt":"2022-05-05T16:24:01","guid":{"rendered":"https:\/\/dianas.web.uah.es\/journal\/?p=4262"},"modified":"2022-05-05T18:24:01","modified_gmt":"2022-05-05T16:24:01","slug":"dianas-2022-11-1-e202203d06-soto-etal-mir-182-5p-and-mir-138-5p-regulate-nogo-a-nogo-receptor-expression-promoting-neurite-outgrowth-in-neural-cells","status":"publish","type":"post","link":"https:\/\/dianas.web.uah.es\/journal\/dianas-2022-11-1-e202203d06-soto-etal-mir-182-5p-and-mir-138-5p-regulate-nogo-a-nogo-receptor-expression-promoting-neurite-outgrowth-in-neural-cells\/","title":{"rendered":"dianas 11 (1) Soto etal 2022 MiR-182-5p and miR-138-5p regulate Nogo A\/ Nogo receptor expression, promoting neurite outgrowth in neural cells."},"content":{"rendered":"<div class='ad_single_article'>\n<p class='ad_single_article_SO'><a href='https:\/\/dianas.web.uah.es\/journal\/dianas-11-1\/#dianas-2022-11-1-e202203d06-soto-etal-mir-182-5p-and-mir-138-5p-regulate-nogo-a-nogo-receptor-expression-promoting-neurite-outgrowth-in-neural-cells'>dianas 11(1)<br \/><\/a> &gt; <a href='https:\/\/dianas.web.uah.es\/journal\/dianas-2022-11-1-e202203d06-soto-etal-mir-182-5p-and-mir-138-5p-regulate-nogo-a-nogo-receptor-expression-promoting-neurite-outgrowth-in-neural-cells\/'>article<\/a><\/p>\n\n<p class='signature'>dianas | Vol 11 Num 1 | marzo  2022 | e202203d06<br \/><\/p>\n\n<p class='w_authors ad_single_article_authors'>Altea&nbsp;Soto<br&nbsp;\/>, Manuel&nbsp;Nieto-Diaz<br&nbsp;\/>, Mar\u00eda&nbsp;Asunci\u00f3n&nbsp;Barreda-Manso<br&nbsp;\/>, Teresa&nbsp;Mu\u00f1oz-Galdeano<br&nbsp;\/>, David&nbsp;Reigada<br&nbsp;\/>, Rodrigo&nbsp;M.&nbsp;Maza<br&nbsp;\/><\/p>\n\n<p class='w_address ad_single_article_address'>Grupo Neuroprotecci\u00f3n Molecular &#8211; Hospital Nacional de Parapl\u00e9jicos. Finca la Peraleda s\/n, 45071, Toledo, Espa\u00f1a.<br \/><\/p>\n\n<p class='w_mail ad_single_article_mail'>alteasotoneira@gmail.com<br \/><\/p>\n\n<p class='w_meeting ad_single_article_meeting'>VII Congreso de Se\u00f1alizaci\u00f3n Celular, SECUAH 2022.<br \/><br \/>\n14 a 18 de marzo, 2022. Universidad de Alcal\u00e1. Alcal\u00e1 de Henares, Madrid. Espa\u00f1a.<br \/><\/p>\n\n<p class='w_abstract_caption ad_single_article_abstract_caption'>Resumen<\/p>\n<p class='w_abstract ad_single_article_abstract'>Durante el desarrollo posnatal, las neuronas del sistema nervioso central (SNC) pierden su capacidad de regeneraci\u00f3n en parte debido a la presencia de inhibidores del crecimiento axonal asociados a mielina como son Nogo-A, OMgp o MAG. Concretamente, Nogo-A se expresa en la superficie de los oligodendrocitos produciendo la inhibici\u00f3n del crecimiento neur\u00edtico\/axonal mediante la uni\u00f3n a su receptor, NgR1, ubicado en las neuronas del SNC. La implicaci\u00f3n de Nogo-A en neurodegeneraci\u00f3n ya ha sido descrito en diversas enfermedades neurodegenerativas como esclerosis m\u00faltiple, Alzheimer o esclerosis lateral amiotr\u00f3fica, as\u00ed como en lesiones traum\u00e1ticas del SNC como lesi\u00f3n medular (LME) y cerebral. Tras un da\u00f1o al SNC, se producen cambios en la expresi\u00f3n de numerosos genes que juegan papeles importantes en procesos de regeneraci\u00f3n axonal, como Nogo-A y NgR1, los cuales a su vez pueden estar regulados por diferentes microARNs. Los microARNs son reguladores postranscripcionales implicados en procesos de diferenciaci\u00f3n neuronal, sinaptog\u00e9nesis, plasticidad o crecimiento neur\u00edtico, entre otros. Por ejemplo, miR-133b, miR-135a-5p y miR-29a regulan el crecimiento neur\u00edtico y la regeneraci\u00f3n axonal a trav\u00e9s de la regulaci\u00f3n de RhoA, ROCK1\/2 y PTEN, respectivamente. <\/p><\/p>\n\n<div class='ad_single_article_citation_box'>\n<\/div>\n\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,94,62,64],"tags":[],"class_list":["post-4262","post","type-post","status-publish","format-standard","hentry","category-article","category-dianas-vol-11-num-1","category-sesion-d","category-vols-10-19"],"_links":{"self":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/posts\/4262","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/comments?post=4262"}],"version-history":[{"count":0,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/posts\/4262\/revisions"}],"wp:attachment":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/media?parent=4262"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/categories?post=4262"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/tags?post=4262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}