{"id":4322,"date":"2022-05-08T10:09:08","date_gmt":"2022-05-08T08:09:08","guid":{"rendered":"https:\/\/dianas.web.uah.es\/journal\/?p=4322"},"modified":"2022-05-08T10:09:08","modified_gmt":"2022-05-08T08:09:08","slug":"dianas-2022-11-1-e202203fp01-lopez-barona-etal-desarrollo-teorico-de-high-throughput-screening-hts-para-encontrar-inhibidores-de-jak2v617f-destinados-a-pacientes-con-policitemia-vera","status":"publish","type":"post","link":"https:\/\/dianas.web.uah.es\/journal\/dianas-2022-11-1-e202203fp01-lopez-barona-etal-desarrollo-teorico-de-high-throughput-screening-hts-para-encontrar-inhibidores-de-jak2v617f-destinados-a-pacientes-con-policitemia-vera\/","title":{"rendered":"dianas 11 (1) L\u00f3pez-Barona etal 2022 Desarrollo te\u00f3rico de high throughput screening (HTS) para encontrar inhibidores de JAK2V617F destinados a pacientes con policitemia vera."},"content":{"rendered":"<div class='ad_single_article'>\n<p class='ad_single_article_SO'><a href='https:\/\/dianas.web.uah.es\/journal\/dianas-11-1\/#dianas-2022-11-1-e202203fp01-lopez-barona-etal-desarrollo-teorico-de-high-throughput-screening-hts-para-encontrar-inhibidores-de-jak2v617f-destinados-a-pacientes-con-policitemia-vera'>dianas 11(1)<br \/><\/a> &gt; <a href='https:\/\/dianas.web.uah.es\/journal\/dianas-2022-11-1-e202203fp01-lopez-barona-etal-desarrollo-teorico-de-high-throughput-screening-hts-para-encontrar-inhibidores-de-jak2v617f-destinados-a-pacientes-con-policitemia-vera\/'>L\u00f3pez-Barona etal<br \/><\/a><\/p>\n\n<p class='signature'>dianas | Vol 11 Num 1 | marzo  2022 | e202203fp01<br \/><\/p>\n\n<p class='w_title ad_single_article_title'>Desarrollo te\u00f3rico de <i>high throughput screening<\/i> (HTS) para encontrar inhibidores de JAK2<sup>V617F<\/sup> destinados a pacientes con policitemia vera<br \/><\/p>\n\n<p class='w_authors ad_single_article_authors'>Patricia&nbsp;L\u00f3pez-Barona<br&nbsp;\/>, Yuliia&nbsp;Fatych<br&nbsp;\/>, Yoel&nbsp;Garrosa-Mir\u00f3<br&nbsp;\/>, Jorge&nbsp;Recio-Aldavero<br&nbsp;\/>, Cristina&nbsp;Zuazo<br&nbsp;\/><\/p>\n\n<p class='w_address ad_single_article_address'><b>1.&nbsp;<\/b>Departamento de Biomedicina y Biotecnolog\u00eda, Facultad de Farmacia, Universidad de Alcal\u00e1, 28871 Alcal\u00e1 de Henares, Madrid, Espa\u00f1a.<br \/>&nbsp; <b>2.&nbsp;<\/b>Departamento de Biolog\u00eda de Sistemas, Facultad de Medicina, Universidad de Alcal\u00e1, 28871 Alcal\u00e1 de Henares, Madrid, Espa\u00f1a.<br \/>&nbsp; <b>3.&nbsp;<\/b>Departamento de Qu\u00edmica Org\u00e1nica e Inorg\u00e1nica, Facultad de Farmacia, Universidad de Alcal\u00e1, 28871 Alcal\u00e1 de Henares, Madrid, Espa\u00f1a.<br \/><\/p>\n\n<p class='w_meeting ad_single_article_meeting'>VII Congreso de Se\u00f1alizaci\u00f3n Celular, SECUAH 2022.<br \/><br \/>\n14 a 18 de marzo, 2022. Universidad de Alcal\u00e1. Alcal\u00e1 de Henares, Madrid. Espa\u00f1a.<br \/><\/p>\n\n<p class='w_abstract_caption ad_single_article_abstract_caption'>Resumen<\/p>\n<p class='w_abstract ad_single_article_abstract'>La policitemia vera (PV) es una neoplasia mieloproliferativa cr\u00f3nica para la que, actualmente, no existe cura. La sintomatolog\u00eda inespec\u00edfica de dicha enfermedad retrasa, adem\u00e1s, el diagn\u00f3stico correcto y el establecimiento de un r\u00e9gimen terap\u00e9utico adecuado. El tratamiento de primera l\u00ednea es meramente paliativo. No obstante, como segunda l\u00ednea de tratamiento en los casos m\u00e1s graves, se ha empezado a utilizar el Ruxolitinib, un inhibidor inespec\u00edfico de JAK1\/2 relacionado con efectos adversos (EA) severos.<\/p><\/p>\n\n<div class='ad_single_article_citation_box'>\n<\/div>\n\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,94,47,64],"tags":[],"class_list":["post-4322","post","type-post","status-publish","format-standard","hentry","category-article","category-dianas-vol-11-num-1","category-full-paper","category-vols-10-19"],"_links":{"self":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/posts\/4322","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/comments?post=4322"}],"version-history":[{"count":0,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/posts\/4322\/revisions"}],"wp:attachment":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/media?parent=4322"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/categories?post=4322"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/tags?post=4322"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}