{"id":711,"date":"2024-03-16T08:46:44","date_gmt":"2024-03-16T07:46:44","guid":{"rendered":"https:\/\/secuah.web.uah.es\/2024\/?p=711"},"modified":"2024-03-16T08:46:44","modified_gmt":"2024-03-16T07:46:44","slug":"dianas-2024-13-1-e202403x040-diaz-gago-etal-las-celulas-tumorales-tiroideas-dependen-de-la-autofagia-y-de-la-respiracion-mitocondrial-para-resistir-a-la-inhibicion-de-brafv600e","status":"publish","type":"post","link":"https:\/\/dianas.web.uah.es\/journal\/dianas-2024-13-1-e202403x040-diaz-gago-etal-las-celulas-tumorales-tiroideas-dependen-de-la-autofagia-y-de-la-respiracion-mitocondrial-para-resistir-a-la-inhibicion-de-brafv600e\/","title":{"rendered":"dianas 13 (1) D\u00edaz-Gago etal 2024 Las c\u00e9lulas tumorales tiroideas dependen de la autofagia y de la respiraci\u00f3n mitocondrial para resistir a la inhibici\u00f3n de BRAFV600E."},"content":{"rendered":"<div class='ad_single_article'>\n<p class='ad_single_article_SO'><a href='https:\/\/dianas.web.uah.es\/journal\/dianas-13-1\/#dianas-2024-13-1-e202403x040-diaz-gago-etal-las-celulas-tumorales-tiroideas-dependen-de-la-autofagia-y-de-la-respiracion-mitocondrial-para-resistir-a-la-inhibicion-de-brafv600e'>dianas 13(1)<br \/><\/a> &gt; <a href='https:\/\/dianas.web.uah.es\/journal\/dianas-2024-13-1-e202403x040-diaz-gago-etal-las-celulas-tumorales-tiroideas-dependen-de-la-autofagia-y-de-la-respiracion-mitocondrial-para-resistir-a-la-inhibicion-de-brafv600e\/'>D\u00edaz-Gago etal<br \/><\/a><\/p>\n\n<p class='signature'>dianas | Vol 13 Num 1 | marzo  2024 | e202403x040<br \/><\/p>\n\n<p class='w_title ad_single_article_title'>Las c\u00e9lulas tumorales tiroideas dependen de la autofagia y de la respiraci\u00f3n mitocondrial para resistir a la inhibici\u00f3n de BRAF<sup>V600E<\/sup><br \/><\/p>\n\n<p class='w_authors ad_single_article_authors'>Sergio&nbsp;D\u00edaz-Gago<br&nbsp;\/>, Javier&nbsp;Vicente-Guti\u00e9rrez<br&nbsp;\/>, Jos\u00e9&nbsp;Manuel&nbsp;Ruiz-Rodr\u00edguez<br&nbsp;\/>, Antonio&nbsp;Chiloeches<br&nbsp;\/>, Pablo&nbsp;Baquero<br&nbsp;\/><\/p>\n\n<p class='w_address ad_single_article_address'>Universidad de Alcal\u00e1.<br \/><\/p>\n\n<p class='w_mail ad_single_article_mail'>sergio.diazgago@uah.es<br \/><\/p>\n\n<p class='w_meeting ad_single_article_meeting'>IX Congreso de Se\u00f1alizaci\u00f3n Celular, SECUAH 2024.<br \/><br \/>\nXVIII Simposio de Dianas Terap\u00e9uticas.<br \/><br \/>\n18 a 22 de marzo, 2024. Universidad de Alcal\u00e1. Alcal\u00e1 de Henares, Madrid. Espa\u00f1a.<br \/><\/p>\n\n<p class='w_abstract_caption ad_single_article_abstract_caption'>Resumen<\/p>\n<p class='w_abstract ad_single_article_abstract'>El carcinoma anapl\u00e1sico tiroideo (ATC) es el subtipo de c\u00e1ncer de tiroides m\u00e1s agresivo y, aunque es poco frecuente (1-2% de todos los c\u00e1nceres de tiroides), presenta una supervivencia media muy baja (3-6 meses despu\u00e9s del diagn\u00f3stico). La prote\u00edna oncog\u00e9nica que aparece con m\u00e1s frecuencia en los ATC es BRAF<sup>V600E<\/sup>, la cual provoca la activaci\u00f3n constitutiva v\u00eda de se\u00f1alizaci\u00f3n de las prote\u00ednas quinasas activadas por mit\u00f3genos (MAPKs), favoreciendo as\u00ed la progresi\u00f3n tumoral. Aunque el uso de inhibidores selectivos de BRAF<sup>V600E<\/sup> muestran cierta respuesta, en muchos de los casos se desarrollan resistencias, por lo que es necesaria la b\u00fasqueda de nuevas terapias para el tratamiento de tumores con dicha mutaci\u00f3n.<\/p><\/p>\n\n<div class='ad_single_article_citation_box'>\n<\/div>\n\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,5,6,8,72,74,37,64],"tags":[],"class_list":["post-711","post","type-post","status-publish","format-standard","hentry","category-_2024_5","category-article","category-cancer","category-comunicacion-oral","category-dianas-vol-13-num-1","category-secuah-2024","category-sesion-5","category-vols-10-19"],"_links":{"self":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/posts\/711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/comments?post=711"}],"version-history":[{"count":0,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/posts\/711\/revisions"}],"wp:attachment":[{"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/media?parent=711"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/categories?post=711"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dianas.web.uah.es\/journal\/wp-json\/wp\/v2\/tags?post=711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}