dianas 9(1) > San-Isidro etal

dianas | Vol 9 Num 1 | marzo 2020 | e202003e03

Study of utility of liposomes in drug delivery.

Elisa San Isidro^a, Elena de la Torre-Rubio^b, Judith Recio^c, Alberto Cook^d

Departamento de Biología de Sistemas, Facultad de Medicina, Universidad de Alcalá (UAH). Alcalá de Henares (Madrid).

a. elisasanisidro@gmail.com  b. delatorrerubio.elena@gmail.com  c. judithrecio1997@gmail.com  d. mcooky_8@hotmail.com

V Congreso de Señalización Celular, SECUAH 2020.
16-18 de marzo, 2020. Universidad de Alcalá. Alcalá de Henares, Madrid. España.

Keywords: EVAC, Liposomas, análogo sintético, RUNX2, miRNA, aptámero

Abstract

Liposomes are known to be goodsynthetic vesicles making up by a lipidbilayer that create a hidrophilicenviroment inside. The composition of this bilayer can be design and modifychemically to enhance its stability and functionality. It could be use in medicine as driving vehicles and theycan transport polar drugs inside themthat could insert easily into cells byendocytosis. Herein, we pretend to make a theoretical study of directedtherapy using liposomes with aptamersbinding to the layer to directspecifically to target cells. We havecombined a synthetic analogue of theligand of our therapeutic target in itssurface rising the specificity of liposomes. This synthetic analogue waschosen by a HTS essay using a molecular modeling software where wehave changed diferents aminoacids of the ligand in order to increase theaffinity to its receptor and block thesignaling pahtway. Furthermore, weaim for the liposome to take a miRNAas a drug, developing a novel treatmentfor Calcific Aortic Valve Desease (CAVD).