dianas 11(1) > Sánchez-Esteban etal
dianas | Vol 11 Num 1 | marzo 2022 | e202203b02
Integrin Linked Kinase Expression In Human Valvular Endothelial Cells Plays A Protective Role In Calcific Aortic Valve Disease.
a. sandrasanchez07@hotmail.com
VII Congreso de Señalización Celular, SECUAH 2022.
14 a 18 de marzo, 2022. Universidad de Alcalá. Alcalá de Henares, Madrid. España.
Keywords: Aortic valve stenosis; Calcification; Endothelial function; Cell signaling
Abstract
Calcific aortic valve disease (CAVD) is the most common valvular heart disease in the aging population.CAVD is a highly active ossification process originated in valvular interstitial cells which differentiate towards an osteoblastic phenotype. However, the role of valvular endothelial cells in CAVD has not been fully explored. We previously demonstrated that ILK expression in vascular endothelium plays an essential cardioprotective role. We hypothesize that endothelial ILK plays a protective role in human valvular endothelial cells osteogenesis.
Citation: Sánchez Esteban, Sandra; Reventún, Paula; Castro, Mercedes; Cook Calvete, Alberto; Delgado Marín, María; Benito, Lucía; Hernández, Ignacio; López Menéndez, Jose; Zaragoza, Carlos; Saura, Marta (2022) Integrin Linked Kinase Expression In Human Valvular Endothelial Cells Plays A Protective Role In Calcific Aortic Valve Disease. Proceedings of the VII Congreso de Señalización Celular, SECUAH 2022. 14 a 18 de marzo, 2022. Universidad de Alcalá. Alcalá de Henares, Madrid. España. dianas 11 (1): e202203b02. ISSN 1886-8746 (electronic) journal.dianas.e202203b02 https://dianas.web.uah.es/journal/e202203b02. URI http://hdl.handle.net/10017/15181
Copyright: © Sánchez-Esteban S, Reventún P, Castro M, Cook-Calvete A, Delgado-Marín M, Benito L, Hernández I, López-Menéndez J, Zaragoza C, Saura M. Some rights reserved. This is an open-access work licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. http://creativecommons.org/licenses/by-nc-nd/4.0/
